Today, my wife had our first-born child. She has a rare genetic defect that our child would only get if I was a carrier so before we decided to have kids I was tested and found out I was not a carrier so there was no way our child could get the disease. He did. FML
I agree, your life sucks (45817) - you totally deserved it (1868)
On 09/21/2009 at 2:24pm - kids - by cheated (man) - United States (Michigan)
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Someone get rid of this ---^
Tried to moderate this FML out because it's far too common a fake FML. Either she cheated on you with a dude who has a "fake" genetic disease (highly unlikely) or your doctor lied to you.
#5 - On 09/21/2009 at 5:10pm by Mirequetz
(-3)Too many negative votes, comment buried. Show the comment.
Someone get rid of this ---^
Tried to moderate this FML out because it's far too common a fake FML. Either she cheated on you with a dude who has the same "rare" genetic defect (highly unlikely)... or your doctor was wrong... or you're a bored douche
#8 - On 09/21/2009 at 5:12pm by Mirequetz
(0)Learn genetics. If two people are carriers, their kid has at least a 25% chance of getting the disease. If the wife actually has the disease, and the husband (or some other guy) is a carrier, the probability that the kid has the disease shoots up to 50%.
(-3)Too many negative votes, comment buried. Show the comment.
thank you fxdect... for that third grade insight into what the genetic possibilities of their child might be, but anyway am i the only one that seems to care that the money that gets spent from this point on should be spent on trying to cure or at least comfort their newborn child? Surely that is what is most important now.
#42 - On 09/21/2009 at 5:35pm by suaveneanderthal
(+2)Not if its a recessive trait, in which case two alelles must be present for the disease to occur in the child.
YOU learn genetics, fxdxhk90.
#56 - On 09/21/2009 at 5:49pm by charmer1862
(+1)i am majoring in biology and am especially interested in genetics. if a trait is recessive and both parents are carriers, the kid really DOES have a 25% chance of inheriting the disease. if one parent has the disease and the other is a carrier, it DOES go up to 50%. learn how to use a f***king punnett square dumba$$es. fxdxhk90 is correct. if even one parent is homozygous dominant, the kid has no chance of getting the recessive disease, but could be a carrier.
FYL dude, but your resources should go into helping your child and not really worrying as much about the affair.
#62 - On 09/21/2009 at 6:00pm by LeCielNousAide
(-4)Too many negative votes, comment buried. Show the comment.
your son got the X chromosome carrying the trait for the disease from your wife, and the normal Y chromosome from you. It's basic biology. If your doctor told you that, he was wrong, if you looked it up, the internet was wrong,.
#66 - On 09/21/2009 at 6:06pm by fatehatesme09
(0)You are Dbag #1 congrats =)
Anyway, my cousin’s son was born with such a disease. He died at age 2. I know how hard it can be.
(+2)kay, so biology people who think they know everything here. there's no way you can diagnose from those two lines. no where does it specify if the name of the disease or whether it's sex-linked or one of the many other types at all. and if it is sex-linked he's right.
XXc + XY = XX, XY, XXc, or XcY
notice, they said daughter, she can't freaking get the disease if he's not a carrier, which he's not. so why don't you two learn YOUR biology.
#73 - On 09/21/2009 at 6:24pm by the_stereotype
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loser haha sucks for you
#74 - On 09/21/2009 at 6:25pm by bugmenotmofo
(0)Sorry to point it out, but you forgot about multiple allele inheritance. I've got basically the same background but am a little farther along. The other day I was giving a presentation about a clinical case that happened at the local university hospital (it's kinda rare). Basically, there was a father that had Sickle Cell Trait (think carrier except can show minor symptoms). The mother was diagnosed with Iron Deficient Anemia, but was tested and shown to not be a carrier for Sickle Cell. The kid's red blood cells were sickling.
So what's up, where did the Punett Square fail? It turned out that Beta Thalassemia Minor is commonly misdiagnosed as Iron Deficient Anemia (the mother's blood tests revealed that she was was iron overloaded due to taking iron pills). Both Beta Thalassemia and Sickle Cell are mutations in the beta chain of hemoglobin (so the same gene). The kid inherited both defects and got, for all intensive purposes, Sickle Cell.
So, assuming the OP is the father of the child, he likely was a carrier for a similar disorder. A lot of tests are too specific for the target disease to pick something like that up. Unless of course it was a genetic test where they sequenced the entire gene (unlikely), at which point the only explanation would be a spontaneous mutation (always a possibility).
(0)LeCielNousAide - OH wow... A biology major. Nice to see that you can use a punnet square (your mother must be so proud), but how about learning some simple genetics first. I know that there is very little information presented in the FML post, but if the OP has stated that the child couldn't get the disease if he wasn't a carrier then the disease is most likely recessive. For a recessive trait to manifest phenotypically, the person needs to have both alleles. The mother has the disease, so let's do this, where N is normal, n is the genetic disease:
n n
N Nn Nn
N Nn Nn
Because the mother has it the disease is not likely to be sex linked, as most disorders are carried on the y chromosome. Which (unfortunately I feel the need to remind you) she doesn't have. The child can only be Nn, and if the disease is recessive they can't inherit it! They need to have a "nn" genotype. So where would the extra "n" come from? .... magic???
Punnet square THAT, idiot.
It's most likely that they made a mistake in the genetic test, but then again we haven't been provided with enough information to make a reasonable conclusion.
#102 - On 09/21/2009 at 6:58pm by fireandice27
(0)Apparently my responses (even though quite valid) is causing sand in someone vag. Seriously, get over it.
Anyone can say "I have a PhD and know what I'm talking about".
This site is starting to fail, it started out so well too.
#105 - On 09/21/2009 at 7:03pm by Mirequetz
(0)I love genetics. Glad to see others know what they're talking about.
#106 - On 09/21/2009 at 7:03pm by randomoutburst
(0)um. that's pretty much the point I was making...way to be repetitive. biology and genetics are something I'm good at I've taken AP biology and obviously I'm a freshman in college so I haven't specialized in genetics yet but I'm planning to. sorry if a Punnett square helps me because I'm a visual learner.
#108 - On 09/21/2009 at 7:04pm by LeCielNousAide
(0)the reason you're getting shit is because you cant spell out dumbass and fucking on a website for some reason... and also because your post made everything seem so cut and dry. The farther into genetics and biology you actually go (and im not talking about AP biology, they can teach monkeys to pass that test) the more you realize that the 50-50 25-75 and all that is so much more complicated than that. No trait is carried on one allele like they teach you in high school bio, they just tell you that shit so that you can wrap your brain around the concept. you should google gregor mendell (sp?) and look at just how much info he had to bullshit on his pea plants to make his punnet squares look the way he thought they should of.
#112 - On 09/21/2009 at 7:20pm by suaveneanderthal
(0)dude the fml says that the guy ISNT a carrier, therefore, if its recessive, there is no way the kid can get the disease
(0)@102:actually most sex linked disease traits occur on the X chromosome, the Y chromosome doesn't carry much more than the gene that causes testosterone production and thus results in a male baby...so there is a chance there was a misunderstanding and it is a sex linked disease, in which the father would pass on a healthy Y chromosome, but the mother would pass on a defective X...and the end suggests that the baby is a male, which would not be surprising that he would get the disease.
I would bet on either the father being a carrier for a mutation in a similar pathway as suggested before, or that there was some kind of mutation...as it has also been stated, genetics is not so cut and dry like other disciplines, there are many different ways to cause the same problem so it doesn't automatically mean he isn't the father of the child.
And yes, while anyone can say they have a degree in something or know it, it really doesn't matter unless they know their shit...and at the same time majoring in something doesn't mean you know everything there is to know about it...I have a BS in genetics but I am fully aware I do not know everything there is to know.
(0)Well theres a few things that could of happened (puts on geekcap)
1. The lab could of made a mistake.
2. The husband could be a mosaic where different cells of his body could have different DNA so that the cell samples collected (assuming they had collected/tested more than one like a good lab should) all had the same non-carrier DNA but some of the cells that would develop into sperm had the carrier DNA and guess what fertilized that egg? Meaning daddy is both a carrier and non carrier (and potentially an affected individual). Still if this happened you could still probably blame the lab for not getting enough samples and from different areas.
3. A trisomic rescue could have occurred where the father's healthy sperm (23 chromosomes/normal amount for humans) fused with the mother's egg but this egg had 24 chromosomes (one extra chromosome resulting in two copies of a chromosome that contained the diseased gene(s)) resulting in a zygote with 47 chromosome (normal = 46 for humans). When this happens a trisomic rescue can occur but not always where one of the extra chromosomes (three total now in the zygote, 1 from dad + 2 from mom) is destroyed however the chromosome destroyed is chosen at what seems like random (the selection mechanism is not yet known) so if the husbands good, healthy copy of the chromosome got deleted then that would leave the child with two of mommy's bad copies and resulting in a sick baby.
But the above except for the first possibility is rare and unlikely, 3 being extremely rare. But if I had a child with someone I'd like to know for sure 100% that shes unfaithful so more expensive testing for me or maybe you could sue the lab/hospital/firm since they predicted it wrong.
And whats with the asshole comments? Dam just give a guy the slightest bit of knowledge and he becomes an ass trying tell off other people with his basic middle/high school biology.
No I am not a bio major, I just happen to like this sort of stuff plus bio tech.
#123 - On 09/21/2009 at 8:05pm by MasterChilin
(0)It's called sex-linked traits, moron. This FML means that either 1) the doctors fucked up or 2) we have a cheating wife. Guess which is more likely.
#127 - On 09/21/2009 at 8:26pm by InfectedWithDrew
(0)You forgot the most obvious and most likely solution: (C) This FML is total bullshit. Just like 99% of all the rest.
#130 - On 09/21/2009 at 8:56pm by capthavoc123
(0)#73 he said that "he did", emphasis on he, meaning son. learn to read. plus, i've spent enough time in bio class to tell whether or not a disease is sex linked.
#135 - On 09/21/2009 at 9:24pm by fatehatesme09
(0)#62 i hate people who curse just because they're trying to tell people that they're right. we get what you're trying to say (for the record I understood punnett squares before hand), just don't rub our noses in it you SOB.
#138 - On 09/21/2009 at 9:28pm by fatehatesme09
(0)Well, there are a lot of genetic disorders (about 4000), and most of them doctors don't know a lot about. Many disorders have tests to prove them that aren't 100% accurate. I have a disorder with a genetic test that is only accurate half the time, so they just do a physical exam to prove it. It's dominant, so it's a lot easier to find and trace within family traits, but with something recessive, it would be really hard if the testing is not totally accurate.
So basically, the testing being inaccurate is not so far fetched, but if you're that paranoid, then get a paternity test.
(0)He didn't have to HAVE the disease, he had to be a CARRIER of the disease. Remember those Punnet Squares in high school biology? A carrier is someone who doesn't have the disease, but has the recessive gene for the disease. You have two genes for most traits, and you can either have two recessive, two dominant, or one dominant and one recessive. If you have one dominant and one recessive gene, you don't have the disease, but if you have a child with someone who does or has another recessive gene, your child has a chance of having the disease. I hope that's good enough of an explanation for all the people on here that slept through biology.
(0)Your argument is mostly sound and mostly true, LeCielNousAide. There is one big exception that is often overlooked, and if the exception is taken into consideration, than the OP could quite possibly be the biological father of the child.
There are certain alleles that are specific to the sex chromosomes. We'll do this simply, and use this FML as an example, and we are assuming that:
The mother expresses the genetic defect.
This defect is X-chromosome specific.
And for simplicity sake, we will label this defect as "d."
And "d" is recessive.
The child born is male.
The mother's phenotype does in fact express this defect, so she is homozygous d. Since she is homozygous d, than there is a 100% chance that allele d will be passed to all of her offspring. Since d is carried on the X-chromosome and the father is not a carrier, than all female offspring, because they have one X-chromosome with the defect and one without, will be carriers of the allele, but will not express it in their phenotypes. However, all male offspring, because they only have one X-chromosome, will all be born with the defect. Since the offspring is male, than it had no chance, either way.
With all of this in mind, it is entirely possible that the OP is the father.
Sorry if this is hard to follow, everyone. I'm only a marine bio major, and it has been awhile since I've sat in a lower level bio class where they teach all this stuff and try to explain it to the itty bitty freshmen.
Good luck, OP. Have a paternity test done. There is a very good chance that it is. I hope so. It's so hard on a child when s/he thinks or knows that s/he is not really their daddy's baby.
#159 - On 09/21/2009 at 11:39pm by hot_mess88
(0)Ummm. Why are you calling me a dumbass? The father ISN't a carrier, so none of what you're saying applies to the stituation. Read the FML.
Lets use the letter T for this. If its recessive, and the mother *has* the disease, she must be TT. If the father isn't a carrier, he must be tt. Therefore, the child can only be Tt, and then the child is a carrier but doesn't have the diease. I mean, yeah, you've got your genetic facts straight, LeCielNousAide, but I think you misunderstood the FML.
#166 - On 09/22/2009 at 12:44am by charmer1862
(0)you know, paternity doesn't garuantee fatherhood. I know biological fathers who have nothing to do with their children, and men who know they aren't the father who love the child just the same.
You are shallow, mean spirited person.
#168 - On 09/22/2009 at 12:58am by alwaysalady
(0)Wow, you sure raped genetics in the ass there.
Despite what you've been told in elementary, this kind of thing doesn't have 4 different possibilities, it has many more than that.
#175 - On 09/22/2009 at 2:12am by TysonFawlay
(0)That's only if the trait is sex-linked. . . Get your facts straight
#179 - On 09/22/2009 at 5:36am by redoleander
(0)i bet you all play world of warcraft...
there's a world outside your computer screen, by the way. sometimes it's good to explore it
#197 - On 09/22/2009 at 3:36pm by repyourcliche
(0)DUde, thats like highschool stuff w/the punnett squares. Just Sayin
#200 - On 09/22/2009 at 6:08pm by Rouge_Plague
(0)lmao. lames. ur getting a ninth grade subject wrong, and you think you're smart.
#227 - On 03/27/2010 at 7:50pm by elainawilson94
(0)you probaly got all of Thai off wikipedia so every one shut up
#229 - On 05/13/2010 at 10:59pm by skullbashd
(0)everyone is arguing about this that you need to recessive traits in order to get it but yes multiple alleles means that you can get two alleles from one parent so she could have gotten two recessive traits from the mother
#231 - On 07/30/2010 at 2:17am by corbincorbin
(0)well i know that's what I didn't get. The OP's name is "cheated" so if that was the case his wife is just an idiot and a whore.. Sorry OP!
#22 - On 09/21/2009 at 5:19pm by AngelRaven89
(0)
Cause cheating is only referring to intimate relationships? hmmm... :p
#27 - On 09/21/2009 at 5:23pm by JaneDoe_71 (FML Staff)
(0)since when can the staff reply? i want to be on the FML staff gogo!
#72 - On 09/21/2009 at 6:20pm by Polionixon
(0)seriously, jane_doe? that is what the FML is actually implying. the girl can't have the disease if he is the father, and she has the disease, which means he isn't...so yeah, in this case cheating DOES mean it was intimate
#75 - On 09/21/2009 at 6:25pm by the_stereotype
(0)The staff has always been able to reply, boo.
Just look at a few other FMLs or in the blog!
#146 - On 09/21/2009 at 10:14pm by redbluegreen
(0)Exactly. Before you jump to conclusions get blood work done because you could very well still be the father. Theres lots of cases where parents get screened for genetic illnesses and even though they are supposedly cleared, they are still passed on to the children.
Still, Im sorry to hear that your child has inherited a genetic disease. Hopefully with the early detection its effects can be minimized.
(-1)Make a paternity test. Maybe there is a way for the child to get it from just one parent..
#7 - On 09/21/2009 at 5:12pm by bittersweets
(-7)Too many negative votes, comment buried. Show the comment.
tenth
#10 - On 09/21/2009 at 5:14pm by stereopump
(+1)Sorry to hear that, FYL. Either it's a very rare chance, your doctor is telling you some BS or she's slept around.
(0)IT'S A MIRACLE BABY!
I think your wife just had Jesus.
#70 - On 09/21/2009 at 6:13pm by SuperFlyTilliDie
(0)How is this FYL? At least you have a child, while countless millions can never have one of their own. I think you need to stop wallowing in self pity, and show that child more love then you've ever known.
(+1)You do realize that many genetic orders are fatal and the baby could die within days of being born.
(0)#21: I have eczema because I inherited it from my dad. It's hardly fatal.
BTW, the OP says that the wife HAS the genetic defect, and she's apparently survived it.
(0)You know, that's just bullshit on their part. Medicine can only do so much... and the only other explaination I have is that you're not the dad, but that's... awful.
#16 - On 09/21/2009 at 5:16pm by Cyanidical_child
(0)This really sucks. I know most rare genetic diseases are really crappy but I'm sure your genetic counselor, you and your wife will do everything in your power to give your baby a comfortable life.
Possibly they misread the results, the test was not accurate, or there are rare instances in which the baby inherits the two genes required to have the disease from one parent.
Best of luck.
(+1)It's not guaranteed your wife cheated. DNA tests are not 100% accurate. Also, you may have Chimera syndrome. In Chimera syndrome, a person can have more than one DNA, which depends on which part of the body the DNA is taken from. So although the DNA taken from you did not test positive for the rare disorder, the DNA in your sperms may be positive for it.
(+1)Chimera syndrome is very rare though. If OP has two different coloured eyes (heterochromia), that could be one indication. Also, it's just as likely that the tissue the doctors used for the original DNA test contained the same DNA as whatever sperm supposedly impregnated his wife.
But it's far more likely that the genetic test was incorrect for other reasons, OR the wife cheated on him. A simple blood type test and a paternity test will solve the mystery.
#45 - On 09/21/2009 at 5:40pm by kazkazkazkaz
(0)you know, you should compare the blood types and if you are not a compatible (meaning you+wife=kid's type), you will know at that point. If you did make a kids with a blood type that came from both of you, then get some more in depth genetic testing done. There is no reason to spend more than you have to on this one.
(0)why would you post this on FML or be on the day your wife had your child?
#29 - On 09/21/2009 at 5:25pm by Pretty_Tied_Up
(0)I doubt this happened "today" it's the rules of the way things are posted on here that it has to start that way, dur
(0)Why does someone have to ask this on every single FML?
It's a rule that they have to start with "Today..." and probably all of the FMLs on here didn't occur the day they were submitted // posted.
OP: awwh. poor baby (I don't mean that sarcastically, lol.). but someone else probably said this, sometimes people have more than one DNA. Maybe the DNA they tested didn't have the characterisitics of this defect, but maybe the DNA in your sperm does? :3 If not, I'm sorry. That's a sucky way to find out.
#43 - On 09/21/2009 at 5:35pm by SusanaSaysRawrxD
(0)yeah he's not the father. or the they screwed up the test. 99% accurate leaves alot more room for failure than you'd think.
#30 - On 09/21/2009 at 5:25pm by pieofchrist
(0)How come they only tested you? They could've test you AND your wife together (yes I do know your wife has a birth defect) to see BOTH of you guys can have children or not.
#34 - On 09/21/2009 at 5:28pm by OrionStarLight3
(+2)Uh. Don't do anything harsh based on the fact that your child supposedly shouldn't have had some genetic defect but he does. Just share your concerns with your wife and if necessary take a paternity test. Going "He's defected but he shouldn't be cause I'm not a carrier, so she obviously cheated on me!" is a bit rash.
(0)the defect being rare, his wife would have to have some of the most shitty luck to have slept around with a another guy who is a carrier of said defect, OP's close blood relatives excluded of course, that said there is still the off chance that there is a 0.9999% the child could have got it from the mom alone, its never 100% when it comes in to this medical shit, either way FYL and F the kids Life too, for being brought into this world with a defect, i hope its not that bad, good luck with the kid
(0)Surely if the wife had this defect she could pass it on without the man needing it too? Unless it's one which is only passed down through the males, in which case the fact that his wife was a carrier means nothing at all. Going by that I don't see the logic to this FML - let alone the fact that genetic defects are obviously able to come about by random chance or they wouldn't be defects in the first place.
#46 - On 09/21/2009 at 5:40pm by TomFantastic
(+2)46 you seriously need to open a biology book before you type shit like that on the internet. Its called a recessive gene. look it up and you'll understand why that post is bullshit.
#48 - On 09/21/2009 at 5:43pm by suaveneanderthal
(0)#48, if you actually studied genetics, you would realize that it isn't as cut-and-dry as your high school Punnett squares would have you think.
#84 - On 09/21/2009 at 6:36pm by greatnt249
(0)Oh man! You guys sound so cool!!! Talking shit on the internet is so cool!!!! It's like you aren't losers!
(0)"Oh man! You guys sound so cool!!! Talking shit on the internet is so cool!!!! It's like you aren't losers!"
Pot, meet kettle.
#90 - On 09/21/2009 at 6:40pm by greatnt249
(0)Yes, you were being sarcastic. But you were being sarcastic to insult them. It is ironic and hypocritical that you are criticizing people for insulting people on the internet and you finish by...insulting them. Just because you were using sarcasm to insult them doesn't mean you aren't a hypocrite. Nice try though.
#110 - On 09/21/2009 at 7:09pm by ForestFire0
(0)I realize what I was doing. I wasn't actually trying to insult them I just showed them how stupid they sounded. Jesus Christ.
(0)F your life? More like F the kids. Atleast you don't have it.
#47 - On 09/21/2009 at 5:41pm by xxjennafurrxx
(+1)Sucks that he has it but doesn't mean for definite it's not your kid. Love him all the same. My dad questions my own legitimacy on the grounds that I can't roll my tongue! There is a very successful geneticist that chose to pursue such a career when him having blue eyes cause his parents to split. Seeing as they both had brown eyes the father questioned the mother's fidelity. Later in life the same geneticist went on to prove that conception of a child with blue eyes from two brown eyed parents was possible under certain conditions. Technicalities like this are constantly being discovered, and it's disputes like this that provide the driving force.
(0)http://en.wikipedia.org/wiki/Sickle-cell_disease
good example of where the parents should get tested before thinking of having children... when i read this post, i thought about myself, because i and my sister, as well as many of my cousins on my mom's side, have the trait. my cousin has three children, and the two older girls have traits, but not the disease. the son, however does have it. he spent his christmas in a hospital two years back. not fun. just go and do some testings on both yourself and the kid... chances are the doctors eff'd up and missed something.
IMO, "cheated" doesn't mean he was cheated on, persey... but rather he was "cheated" in the fact that he thought he was okay, and that his child would be okay... and they weren't.
just another reason to do research before doing the deed.
(0)There's still a chance it's your kid. Things happen, maybe they mixed up your tests or it turns out that this can be given to children by only one parent's genetic predisposition.
I'm really sorry if she did cheat, but maybe you should hear what she has to say first.
You can always get a DNA test too.
#53 - On 09/21/2009 at 5:46pm by ohreally123
(0)Wow, not only did she cheat, but she managed to find the one other person with that rare disorder? Yikes
(0)I somehow don't get that the point of this website is to show personal tragedies in 160 characters or less... harsh, yes, but I'm inclined to call fake, because who has a disabled/somehow badly affected child, regardless of whether or not its 'theirs' and thinks "oh, I'll post about my bad luck on fml!"
(+1)adopt a kid! seriously!! there are so many unwanted kids in this world!!
#60 - On 09/21/2009 at 5:59pm by explodingpupppet
(0)WOW!!! so not only did she cheat on you, but she cheated on you with a disease infested carrier bastard
#63 - On 09/21/2009 at 6:03pm by cabalthewolf
(0)it happens, statistics say that 10% of children out there are born from fathers whom they do not call their dad
#64 - On 09/21/2009 at 6:03pm by diet_cocaine
(0)I might be way off here, but although to may not of been a carrier, maybe your wifes genes or w.e was stronger so the baby got this defet.
(0)this is just awful! two FMLs in one! your kid has a birth defect and your wife may have cheated on you. hopefully your doctor sucked and read the results wrong...and thus FML cures itself with another FML
#76 - On 09/21/2009 at 6:29pm by the_stereotype
(0)Awww - I hope your baby can still manage :(
BUUUUT. before you conclude something stupid happened, are you SURE it wasn't an x-linked recessive disorder? because then it isn't anyone's fault. it's like color blindness, sort of. the gene mutation is for some gene on the x chrom., but since women have 2, they can be carriers w/o problems because the gene on the other x will save them. BUT. even if they have kids with a problem-free guy, their sons will all get an x from their mom - and if it's the bad version of the gene they get... they don't have a spare x to fish them out of trouble. it's high school bio :(
#77 - On 09/21/2009 at 6:30pm by mrrrfghqueen
(0)I know right.
I feel so overwhelmed being a mere high school student surrounded by graduates holding phDs in genetics on FML.
#161 - On 09/21/2009 at 11:50pm by barlessprison
(0)Really? They're wrong half the time?
You're really better off not talking out of your ass if you have absolutely no clue.
#88 - On 09/21/2009 at 6:38pm by greatnt249
this is sad ): i hope its not a harmful genetic disorder...
#91 - On 09/21/2009 at 6:41pm by yummy_gummybear9
(0)Aw this really suckss. But if your wife had it, and wasn't just a carrier, and was able to have a relationship and all with you, then there's hope for your child yet.
Stupid doctors. You should sue. I would.
#92 - On 09/21/2009 at 6:43pm by ilovesk8rs107
(0)Let's assume that the disorder is autosomal, because you mentioned that it's your daughter. If it were X-linked, for her to even be a carrier, you must, by definition, have the disease as well. Since you don't mention it, I'll assume that's not the case.
Now what if the child were heterozygous for a large deletion in the region? You may have 1 copy of normal DNA, and one copy of non-existent DNA in that region. The test wouldn't pick up the deletion, because PCR and cycle sequencing don't tell you if it's sequencing one or two strands (assuming there are no heterozygosities, which it appears is the case). If you gave your daughter the deletion, and your wife gave her the mutation, she only has one copy of the bad gene, with no good copy to cancel it out, and thus has the disease, even though you aren't a carrier for the specific mutation.
This is all assuming that it's a recessive trait-because if it were dominant, and you don't have the mutation, then your wife must, by definition, have the mutation and thus the disease. Since you don't mention that your wife is affected, I'll assume that that's not the case either. Unless it was a de novo mutation, which do occur, but they are exceedingly rare. Like EXCEEDINGLY rare.
(0)ok the way i read this. is the mother has the.
" She has a rare genetic defect that our child would only get if I was a carrier,"
i read that as the mother has it and can only pass it to the child if father has it (?)
I was not a carrier so there was no way our child could get the disease. He did. FML
he calls the child "he" so was it a boy or a girl ?:|
im lost and know nothing so i'm shutting the fck up : )
#140 - On 09/21/2009 at 9:32pm by catriona_cd
(0)Actually, as the mother of a child with a rare genetic birth disorder, this in fact COULD be true. In order for my daughter to have a child with her disorder the father of the child would have to be a carrier and then there would be a 50% chance of the baby having the disorder.
#96 - On 09/21/2009 at 6:50pm by tinkerbellmama
(0)Even if you're not a carrier, if your wife has a genetic defect carried on the X chromosome and bears a son...the son STILL has a chance of having the defect. A DAUGHTER, however, will NOT get it because she'll have TWO X's, one of which doesn't have the defect. That makes her a carrier if she inherits the gene from her mother.
(+1)I'd just like to say, that all the @$$holes who said that he deserved it are some f**king douches
(0)So its more likely that your wife cheated on you with someone that got that zomg uber rare disease over the test going wrong or the "He can only get it if you are both carriers" was bullshit?
(0)Way to jump to conclusions cheated! Doctors can never predict anything 100% so there may have been a probability your son could have been born with it anyway. Neither my ex or I is autistic, but we have a daughter who is. Neither of us has neurofibromatosis (NF1) but my son has it. It happens. Man up and be your son's dad. Love him and quit bitching about not getting perfection.
(0)Am I the only one who find the ppl who comment on FMLs funny as hell? U guys r fighting over who knows abt chromosomes I would say FYL dude idrc if its fake its not hurting anyone stay on topic ppl and I'm sorry to the OP
(0)This is awful and I'm sorry for you. However, there is an episode of Law & Order SVU just like this. If this is fake I would guess that's the inspiration.
#117 - On 09/21/2009 at 7:52pm by 1ParanoidAndroid
(0)That stinks. I hope the disease isn't too bad for the child, even if it isn't yours.
Before you blame her for infidelity, get a paternity test and get yourself re-tested for the disease (obviously go to a different doctor for your testing, the first one might have screwed up).
(0)This isn't fake. My aunt has cystic fibrosis, and so my uncle got tested for being a carrier. The test he did in canada said they were good to go. Now my cousin has cystic fibrosis because the test was inaccurate. Sure enough he took a test only offered in the states that was more accurate and found he was a carrier.
#121 - On 09/21/2009 at 8:03pm by Winsy
(0)If a genetic disorder is carried on the X chromosome, the child would have a 50% chance of having the defect, being a male child from a female who was a carrier.
However, it sounds like the aforementioned disorder is not one that is carried on the X chromosome. There can be any number of disorders like this - recessive traits carried on one of our other 35 chromosomes. The only way his wife couldn't have cheated on him is if the gene in question mutated...possible but ridiculously unlikely. So quit arguing genetics and feel bad for the guy.
#122 - On 09/21/2009 at 8:03pm by flgirlwguitar
(0)ever heard of punctuation dude run-on sentences are really hard to understand because they don't break up the ideas use commas kthxbi
#125 - On 09/21/2009 at 8:13pm by nishman686
(0)I have not read a lot of the comments posted here but I did want you to know one thing before you assume she cheated. There is a such thing as a sex-linked gene, meaning that a gene is only found on either the X or Y chromosome, not both. Many genetic disorders such as hemophilia are passed from mothers to their sons because the gene for the disorder is only found on the X chromosome. If the mother passes on the trait to her son, he will have the disorder regardless of who the father is because the gene cannot be found on the Y chromosome at all.
However, if the disorder is not from a sex linked gene then I am sorry to say you could only be the father if you were a carrier.
(0)Well obviously if the father had to get tested for it, then it's not a sex-linked trait. . . Doctors had to pass basic Biology to become doctors you know.
#180 - On 09/22/2009 at 5:38am by redoleander
(-4)Too many negative votes, comment buried. Show the comment.
who gives a flying fuck of that POS baby got a disease.. this world is too overpopulated anyway.......
#129 - On 09/21/2009 at 8:33pm by dragonkiller101
(+1)Wow, go kill yourself.
Population control and asshole control, all at once.
#169 - On 09/22/2009 at 1:08am by alwaysalady
(0)seeing as how they were tested before, this means his wife cheated. unless the doctors really screwed up. it is much more likely she cheated. all this sex trait stuff is crap because they were tested and guaranteed the child would not have it. she cheated, end of story. fyl man. i am so very sorry for you :(
#131 - On 09/21/2009 at 8:58pm by mizu22
(0)seeing as how they were tested before, this means his wife cheated. unless the doctors really screwed up. it is much more likely she cheated. all this sex trait stuff is crap because they were tested and guaranteed the child would not have it. she cheated, end of story. fyl man. i am so very sorry for you :(
#132 - On 09/21/2009 at 9:01pm by mizu22
(0)as you mentioned a rare genetic defect. did you mean that she had a thing with her kin.
#134 - On 09/21/2009 at 9:17pm by dreamagain
(0)You should sue the asshole who told you that there was no way your kid could get the disease.
#143 - On 09/21/2009 at 9:39pm by HoneyTiger
(0)As I see it, either this FML is total bullcrap or the doctors screwed up. I doubt the OP's wife would even be able to find someone with the same "rare" genetic disease to cheat on him with. Since FMLs are published with no verifiability, I'm leaning towards the former option. Still, in any case... FYL.
#144 - On 09/21/2009 at 9:46pm by PhoenixElite
(0)hmmm
like this:
n n
N. Nn. Nn
N. Nn. Nn
I really don't know much about genetics but I'm pretty sure this is how a punnet square should look.
#147 - On 09/21/2009 at 10:16pm by rollursk8r
(0)Depending on the disease, it could be a new mutation. Though I'm sure the wife pretty much admitted the cheating immediately.
#149 - On 09/21/2009 at 10:18pm by MoobyTheCow
(+1)damn you're quicker to believe that your wife cheated on you than that the doctor who did the first test mad a mistake?
doesn't really matter if she cheated cause it doesn't sound like you had much of a marriage anyway
(0)YDI for overpopulating the world more with a retarded child that can't work and use are taxes to help them for the rest of there life
(0)This doesn't really make any sense to me. It sounds like the OP is trying to say that his wife cheated on him. But, if the child would only get the defect if both mother and father had it, then the woman would have had to find a man with the same genetic defect, and if it's so rare, that must have been difficult. And how would she find him? Put an ad out? This one just seems too fake to me
#157 - On 09/21/2009 at 11:30pm by PoeticPixie
(+1)So fake. Not only is it terribly structured making it unlikely to be from a parentaged being, but the baby in question changes sex half way through the post.
(0)No SHE doesn't. HE is the guy who his wife cheated with.
#165 - On 09/22/2009 at 12:31am by sadistmonkey
(0)Actually, I believe the "she" referred to at the start of the FML is his wife. NOT the child. "My wife...She has a rare genetic defect...". The baby seems to be male, so it's possible that the disorder was linked to the x-chromosome or, more likely, the doctor's screwed up the test. It happens more often that you would think.
(0)so what?! it's your child. you should love your child no matter what, right?
#163 - On 09/22/2009 at 12:14am by littlemisslee
(0)http://sadtrombone.com/
That sucks.
Wah wah wah wahh!
#167 - On 09/22/2009 at 12:55am by LaughingVeggies
(0)"the baby aint mine, i'm sorry..bitch you heard maury!"
that song popped in my head when i read this, probably a little inappropriate right now though considering the situation..
(+1)If it's a disease like Tay-Sachs or Cystic Fibrosis it's possible that they only tested the most common genes which are known to cause the disease. There are hundreds which are known to potentially play a part, so they'll probably test you again for those genes. I wouldn't be so quick to blame your wife, but if you are of a different ethnicity then the doctor should be aware that some mutations are much more common depending on your ethnicity.
(0)I'm just disappointed the guy called himself "cheated" as the author of the FML. As if it was the only option and as if the situation must not be hard enough for the new mother. I'm guessing she already feels like a failure so a bit of support might be a better idea....
(0)To everyone who is saying that his wife cheated. It may not be the case! I am a psychology major and we just covered this exact topic last week on genetic defects in biospychology class. To the OP your wife is a carrier correct. So if she was carrying a genetic disorder that could be passed to your child it would be in the X chromosome of her egg. Which means that technically since she has two X chromosomes only 1 carries the defect. From reading your post your child is male, correct? Then he has one X chromosome and one Y chromosome. If your son received the genetic defect from your wife's X chromosome he will have the defect whether you are a carrier or not because he does not have another X chromosome to negate the effects of the first gene. I will try and explain it below as simply as I can.
For example: XX = Female, XY = Male. x= genetic defect.
Your wife is a carrier so it would look like this Xx= Normal, but carries the defect or xx, she has the defect.
You are XY and do not have the defect.
However your son is a compilation of you and your wife so it would look like this depending if your wife has the defect or if she is the carrier.
XY = Normal,
xY=Defect.
In short you had no say in the matter since he was male. If you need more convincing get a paternity test.
#183 - On 09/22/2009 at 8:08am by Zealousmerc
(+1)wow nobody here seems to understand genetics. the OP never said it was carried on the X chromosome, the Doctors would have figured that out when they tested him.
(0)Try not to jump to conclusions just yet, the baby can most definitely still be yours. I am a biology major and have studied a lot of genetics. Obviously I do not know what this defect is, but it most definitely could be a sex lined disorder. If it is in fact sex linked, then you would have not played part in your child getting the disorder. Basically females ALWAYS give an X chromosome, because their make up is XX. Males can either give a Y (producing a boy) or an X (producing a girl). Sex linked disorders are almost always caused on the X chromosome. A mother who is a carrier has a 50% chance of giving her son, or daughter, the defected chromosome. Now, if the genetic testing was correct, had you had a girl 50% would be carriers and 50% would be normal, because you don't have the disorder on your X chromosome. However, since your wife does 50% of your son's will have the disorder (since they only have one X chromosome) and 50% will not have it.
For example, if it is X-linked, here is what happens:
Your wife: Xx (little x is the defect)
You: XY (no little x = no defect)
Your son: xY (your wife passed on the defective x while you gave a healthy Y)
Basically if it is X-linked then there is no possible way for you to give your son's the disorder, even if you yourself have it because you are passing on a Y chromosome. If you had a daughter, that would be different.
#185 - On 09/22/2009 at 8:52am by coloringbooks
(0)This thread reminds me of all the amature meterologists that pop up durning hurricane season. Whatever the explaination is whther it is a biological oddity or infidelity I feel bad for OP. I thank God every day that my kids are healthy!
(0)this disease can't be THAT rare, if your wife found someone to cheat on you with that has it... what are the odds?
(0)Okay im glad I got a 98 in biology. for a boy it only takes one of the parents to be a carrier or positive for the disease since a boy is XY (X from the mother and Y from the Father) and the X carries the disease, if his mother is POSTIVE for the disease then he's 100% likely to get it get the disease but if the mother is a CARRIER of it he has a 50% chance of getting it. a girl is XX (X from the mother and X from the father) and again the X carriers the disease. the mother either has to be POSITVE for the disease or a CARRIER of the disease and the father HAS to be POSTIVE for the disease. if the mother is a CARRIER and the father is POSITIVE, the girl will be 100% a CARRIER of the disease but 50% chance of her being POSITIVE for it. but if the father is NEGIVITVE for the disease theres a 50% chance she'll be a CARRIER and a 0% chance she'll be POSITIVE for the disease.
(0)Okay im glad I got a 98 in biology. for a boy it only takes one of the parents to be a carrier or positive for the disease since a boy is XY (X from the mother and Y from the Father) and the X carries the disease, if his mother is POSTIVE for the disease then he's 100% likely to get it get the disease but if the mother is a CARRIER of it he has a 50% chance of getting it. a girl is XX (X from the mother and X from the father) and again the X carriers the disease. the mother either has to be POSITVE for the disease or a CARRIER of the disease and the father HAS to be POSTIVE for the disease. if the mother is a CARRIER and the father is POSITIVE, the girl will be 100% a CARRIER of the disease but 50% chance of her being POSITIVE for it. but if the father is NEGIVITVE for the disease theres a 50% chance she'll be a CARRIER and a 0% chance she'll be POSITIVE for the disease.
(0)depends on the disease, as in huntingdons only one gene is needed as its dominant (so being a carrier is impossible) but then you have used carriers in your argument which confuddles me cos you cant say its 100% that a boy will get this because his mother was positive. also how do u know where the defective allele is in the dna? it could be in any part of the chromosomes. so your percentages dont work for all diseases, and saying that the mother being positive means he will get it is completely rong.
i cant remember the rest, but dont be so sure that jsut cos u got 98 in biology that you know everything about this.
#193 - On 09/22/2009 at 1:40pm by fule123
(0)if the mother is positive for it then both of her allels are affected! if she's a carrier then only one of her allels are affected. so since she's positive for it then she'll pass it onto her SON but if she had a DAUGHTER then the father would have to be positive in order for the daughter to be positive for it! if you want me to I can go back to school that i graduated from last year an ask all 3 Bio teachers there an see if they agree with me!
(0)some genetic issues are more complicated than that. yes, that's the basic way genetics works, but especially with some diseases, different genes affect each other differently and it can be more complicated than what you suggested.
(0)To everyone talking about how this COULD happen, even if he is the father- don't you think their genetic counselor would have told them about those ways?
we don't have enough info from this FML to know what the disease is, or what its mode of inheritance is, so WE THE READERS HAVE NO WAY OF KNOWING IF HE IS NOT LIKELY TO BE THE FATHER. There is some error in genetic testing, but all of that should have been explained by the genetic counselor, and if the disease is X-linked, or involves epigenetics, or we don't know all of the possible genes involved or anything else, and "we" (the scientific/genetic community) know about it, the genetic counselor would have told them. If it's a well characterized disease, and his carrier test wasn't a false negative then he's probably not the biological father, but there are lots of possibilities. And, we're learning new things about diseases and inheritance every day! (Sorry, I'm a PhD student in human genetics, couldn't resist contributing my 2 cents)
#201 - On 09/22/2009 at 6:48pm by spartan_girl
(0)why is everyone so fucking smart here?
dxy + n = jhcxbkdfs - 837u = dj
which means she OBVIOUSLY cheated.
everyone knows that :) "simple biology."
--- what the hell?
(0)"Why the hell are you all talking about Genetics? The point is the child is not his!"
Fool. For starters, they're talking about genetics to demonstrate that the child COULD be his but that the disease has been passed on due to a twist that some genetic diseases have. Secondly, well, that's just it - the child COULD be his, either due to the genetic explanations people are giving OR because the tests were wrong and he does carry the disease gene.
(0)I am just LMFAO at how the peanut gallery has suddenly become genetics experts. Look at them busting out their high school biology.
This is so fucking rich.
(0)Either your disease is actually dominant, or the gene is imprinted.
What imprinted means is that your normal copy of the gene that doesn't have the defect that your wife has was was canceled by a gene transposition because you're male. The resulting disease shows up as haploid in your child, because there's no second allele to prevent the recessive mutation from expressing itself in him/her. Basically, it means your genetics hate you.
#206 - On 09/22/2009 at 10:00pm by beaverteeth92
(0)Oh no, you poor things! What kind of doctor would give you that kind of absolute assurance yet it still happens??
(0)Perhaps your test was wrong? These things happen you know. Doctors are not god and their tests are not fail-proof.
(0)I think it's safe to say many science-inclinded people on here have proved it could be possible for the child to have the disease without any infidelity on the mother's part. There are so many variables when it comes to genetic inheritance. Not much is so cast-in-concrete. And even if his wife DID cheat with someone who was a carrier, favorable odds just weren't on this poor guy's side. :(
#211 - On 09/23/2009 at 8:22pm by italianprincess8
(0)forget genetics. this can happen if your to canadian, look at michael j fox.
#213 - On 09/25/2009 at 2:54am by ladiesman14
(0)is your child a she-male? or is this fake? did you forget that you called her a she at the beginning when you referred to him as a he at the end? FAKE
#214 - On 09/25/2009 at 1:39pm by mvgslhrsfb
(0)You fail at grammar.
"*She* has a rare genetic defect that our child would only get if *I* was a carrier so before *we*decided to have kids..."
The 'she' and 'I' must refer to the parents for the plural pronoun to make sense.
(0)While it is possible, I think this FML is fake simply because no doctor in their right mind would tell you that it was impossible for your child to be born without the disease if you aren't a carrier.
Simple terms, since your child is male he has an X and Y chromosome. Since most genetic disorders occur on the X chromosome, it is nearly impossible for a male to be a carrier, he either has the condition or he doesn't. See, unlike a girl where you can pass on the healthy X chromosome and your wife can pass on the unhealthy X chromosome and still have a healthy daughter (carrier) If you pass on a healthy Y chromosome and your wife passes on a unhealthy X chromosome, your son will be born with the disease.
To all you "biology majors" who think you're the shit, I learned this from my seventh grade bio course. :) You're not that impressive
#216 - On 09/25/2009 at 11:43pm by Bizzytrick
(0)You're all stupid.
He's talking about cystic fibrosis.
And he's not lying.
I know because I have it.
And when I have kids, they won't get it AT ALL if my partner DOESN'T CARRY IT.
Because both my alleles are affected by it, I will pass it on. This will make my kid a carrier, but it won't HAVE the disease.
My boyfriend doesn't have it, but if he is a carrier (having one affected allele), and passes that one on as opposed to the healthy one, it will have it.
So this FML is not fake. It's CF.
(0)I'm sooo sorry.
my parents dont have the disease i was born with, but their both carriers.
its hard but im just glad to be alive, i was born with tar syndrome which messed with my arms.
and i was bow legger before surgery.
My parents had no idea i'd be like this when i was born.
your family is in my prayers.
#221 - On 10/19/2009 at 7:18pm by blakeleyarden
(0)Yo bro, she cheated, dump her and pay child support.
#224 - On 12/31/2009 at 11:58pm by FutureVeteran
(0)omfg 73... ur such a dumbass. it says "He did" but noting about a daughter. obviously the X gene he got was defective and therefore gave him the disease. it's so simple!
